A 78-year-old British gentleman presents with tiredness, poor appetite and weight gain. He has noticed that his voice has become hoarse and deep. His hearing has also worsened over recent months. A photo of the patient is shown below:

1. What is the most likely diagnosis?
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This man has several clinical features consistent with a diagnosis of hypothyroidism. He also has numerous facial features consistent with the diagnosis.

 The typical clinical features of hypothyroidism include:

  • Tiredness and lethargy
  • Cold sensitivity
  • Dry skin
  • Impaired concentration and memory
  • Increased weight
  • Decreased appetite
  • Hoarse voice
  • Reduced hearing / deafness

Image sourced from Wikipedia
Courtesy of Dr. L.F. Herbert et al. CC BY-SA 2.5

2. Give two clinical features that are present in the above photograph that support this diagnosis.
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This patient has several of the typical ‘myxoedema facies’ seen in hypothyroidism, including:

  • Puffiness / oedematous facial appearance
  • Loss of the outer third of the eyebrows
  • Apathetic facial appearance
  • Facial pallor
3. What is the most common cause of this diagnosis in the U.K.?
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The commonest cause of hypothyroidism in the U.K. is autoimmune thyroiditis. When this occurs in combination with a goitre, it is referred to as Hashimoto’s thyroiditis.

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