Anticholinergic Poisoning
Anticholinergic poisoning is a potentially life-threatening toxidrome that occurs following exposure to substances that block acetylcholine at muscarinic and, to a lesser extent, nicotinic receptors. It can result in profound central and peripheral effects, ranging...
Understanding Adverse Drug Reactions
Adverse drug reactions (ADRs) are a significant concern in clinical practice, impacting patient safety and treatment outcomes. The World Health Organization (WHO) defines an ADR as “A response to a drug which is noxious and unintended, and which occurs at doses...
Myxoedema Coma
Myxoedema coma is an extreme manifestation of untreated hypothyroidism and is a life-threatening condition characterised by hypometabolism and altered mental status. It commonly affects elderly patients with long-standing hypothyroidism, often precipitated by...
Levels of Evidence and Grading Systems
Levels of evidence A hierarchical system of classifying evidence is an essential part of evidence-based medicine. This hierarchy is commonly referred to as the levels of evidence. When attempting to find the answer to a clinical conundrum, a clinician should actively...
