Ischaemic Bowel 

Ischaemic Bowel 

Ischaemic bowel disease occurs when there is inadequate blood supply to the intestines, leading to mucosal injury, necrosis, and perforation if untreated. It is a life-threatening emergency with high mortality, particularly in cases of bowel infarction. There are two...
Pertussis

Pertussis

Pertussis, also known as whooping cough, is an upper respiratory tract infection caused by the Gram-negative bacteria Bordatella pertussis. Transmission is via respiratory droplets, and the incubation period is approximately 7-21 days. The disease is highly contagious...
Anticholinergic Poisoning

Anticholinergic Poisoning

Anticholinergic poisoning is a potentially life-threatening toxidrome that occurs following exposure to substances that block acetylcholine at muscarinic and, to a lesser extent, nicotinic receptors. It can result in profound central and peripheral effects, ranging...
Understanding Adverse Drug Reactions

Understanding Adverse Drug Reactions

Adverse drug reactions (ADRs) are a significant concern in clinical practice, impacting patient safety and treatment outcomes. The World Health Organization (WHO) defines an ADR as “A response to a drug which is noxious and unintended, and which occurs at doses...
Myxoedema Coma

Myxoedema Coma

Myxoedema coma is an extreme manifestation of untreated hypothyroidism and is a life-threatening condition characterised by hypometabolism and altered mental status. It commonly affects elderly patients with long-standing hypothyroidism, often precipitated by...
Levels of Evidence and Grading Systems

Levels of Evidence and Grading Systems

Levels of evidence A hierarchical system of classifying evidence is an essential part of evidence-based medicine. This hierarchy is commonly referred to as the levels of evidence. When attempting to find the answer to a clinical conundrum, a clinician should actively...