Cytochrome p450 Enzymes and Drug Metabolism
Many drugs are metabolised in the liver. Drugs are either metabolised by phase I reactions (oxidation, reduction, or hydrolysis) or phase II reactions (e.g. glucuronidation). Phase I reactions are mainly carried out by the cytochrome P450 family of isoenzymes, of...
Building a Career in Global Health and Expedition Medicine
Building a career in global health and expedition medicine – the good, the bad, and the stuff no one tells you! Can I be a neurosurgeon and travel the world with my work? I’d like to do paediatrics but with some humanitarian work- is that possible? Will I still...
Understanding Homeostasis
Homeostasis is the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant. Examples of homeostasis include the regulation of temperature and pH balance. The two body systems that are responsible for...
HELLP Syndrome
HELLP syndrome is a pregnancy complication that usually presents in women who have pre-eclampsia or eclampsia. Affected women also show signs of liver damage and abnormalities in blood clotting. HELLP syndrome is characterised by: Haemolysis ELevated liver enzymes Low...
